Voltage Sensitive Dyes

Low biological noise probe for high-speed neural imaging of electrical signals

OI announces its new “blue” line of high-speed voltage sensitive dyes for cortical imaging, originally synthesized by Rina Hildesheim, and available exclusively from OI (patent pending; blue dye series includes RH-1691, and RH-1692). Voltage sensitive dyes (VSDs) are optical transducers of membrane potential changes. Applied to the brain, they bind to the external surface of the membranes of living cells without interrupting their normal function. Once introduced into a preparation, VSDs rapidly (within a microsecond) alter the intensity and/or wavelengths of fluorescent light they emit as a function of changes in neuronal membrane potential.


Priority in supply of dyes will be given to Optical Imaging’s Brain Imager customers (in case of supply shortage)